Принципы, технологии и устройства "капельной" микрофлюидики. Ч. 2 (обзор)

Принципы, технологии и устройства "капельной" микрофлюидики. Ч. 2 (обзор)

Автор: Кухтевич И.В., Посмитная Я.С., Белоусов К.И., Букатин А.С., Евстрапов Анатолий Александрович

Журнал: Научное приборостроение @nauchnoe-priborostroenie

Рубрика: Приборостроение физико-химической биологии

Статья в выпуске: 3 т.25, 2015 года.

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Обзор представлен в нескольких частях. В первой части обзора изложены следующие темы. - Физика процесса. Образование капель. - Моделирование процессов в "капельной" микрофлюидике. - Устройства для формирования капель. Во второй части приведены разделы: - устройства для слияния капель: пассивные методы и активные методы; - обработка и модификация поверхности; - создание стабильных эмульсий в микрофлюидных устройствах. Здесь подробно обсуждаются базовые топологии микроустройств для слияния капель. Особое внимание уделяется методам и способам модификации рабочей поверхности полидиметилсилоксана - материала, наиболее часто применяемого для прототипирования микрофлюидных чипов. В отдельном разделе представлены способы создания стабильных эмульсий с использованием поверхностно-активных веществ.

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Коалесценция капель, полидиметилсилоксан, модификация поверхности, эмульсия, поверхностно-активное вещество

Короткий адрес: https://sciup.org/14264992

IDR: 14264992   |   УДК: 543.9+532.5.01+532.6+544.7

Principles, technologies and droplet-based microfluidic devices. Part 2 (review)

The active and passive methods and the devices for coalescence of the droplets are considered in the second part of the review. Particular attention is paid to the methods of processing and surface modification of polydimethylsiloxane (the most frequently used material in microfluidics) in order to create the conditions for the stable droplet generation. Depending on the type of the emulsion (water drops in oil transport flow or vice versa) the surface should be hydrophilic or hydrophobic. The surface with the different wetting properties on the various local sections is required at generation of double emulsions. A single part describes the methods of stabilizing the emulsions. Usually the surfactants used for the droplets stabilizing. The surfactant reduces the surface tension between the two fluids through the formation of the oriented film at their interface. However, the choice of an appropriate surfactant should be carefully carried out, since these substances can affect on the components of sample and biomolecules.

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