Profibrotic mediators in assessment of tubulointerstitial changes in surgical treatment of patients with urolithiasis

The aim of present work has been an assessment of degree of tubulointerstitial modifications of kidney parenchyma in patients with urolithiasis in different stages of surgical treatment using non-invasive mediators of nephrofibrosis and angiogenesis. The results of operations of 65 patients have been analysed. The content of nephrofibrosis molecular mediators in blood serum and urine has been determined. It has been shown that the most informative non-invasive mediators of tubulointerstitial fibrosis are IL 12, VEGF in blood serum and b2-microglobulins MG, MCP 1 and NO excreted with urine. Patients with bilateral urolithiasis accompanied by expressive tubulointerstitial damages have had high indices of nephrofibrosis in postoperative period that can indicate irreversibility of these changes, leading to progression of chronic kidney disease.