Прогностическая роль молекулярных подтипов рака толстой кишки. Современный взгляд на проблему

Прогностическая роль молекулярных подтипов рака толстой кишки. Современный взгляд на проблему

Автор: Синянский Лев Евгеньевич, Вторушин Сергей Владимирович, Паталяк Станислав Викторович, Афанасьев Сергей Геннадьевич

Журнал: Сибирский онкологический журнал @siboncoj

Рубрика: Обзоры

Статья в выпуске: 3 т.20, 2021 года.

Бесплатный доступ

Цель исследования - обобщение имеющихся сведений о гетерогенности рака толстой кишки и оценка прогностической значимости его подтипов. Материал и методы. Поиск литературы производился в системах Medline, Cochrane Library, Elibrary и PubMed, включались публикации, характеризующие современный взгляд на проблему выбора стратегии послеоперационного лечения рака толстой кишки. Результаты. В обзоре освещены результаты международных исследований подтипов рака толстой кишки, основанные на комплексных мультиомных характеристиках. Особое внимание уделено описанию современных исследований по поиску прогностических маркеров рака толстой кишки. Проведен анализ мировой литературы, подтверждающий актуальность исследования иммуногистохимических маркеров, которые дадут возможность классифицировать рак толстой кишки на молекулярные подтипы в реальной клинической практике и, следовательно, значительно улучшить эффективность адъювантной терапии.

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Рак толстой кишки, молекулярные подтипы, адъювантная химиотерапия, факторы прогноза

Короткий адрес: https://sciup.org/140254502

IDR: 140254502   |   DOI: 10.21294/1814-4861-2021-20-3-107-114

Список литературы Прогностическая роль молекулярных подтипов рака толстой кишки. Современный взгляд на проблему

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