Prediction of the duration of remission after combined therapy with oxygenhelium mixture inhalations in patients with diabetes mellitus and long-term trophic disorders in the lower extremities

Background. Trophic disorders of the lower extremities in diabetes mellitus and chronic obliterating diseases of the arteries of the lower extremities pose a complex therapeutic problem due to the high risk of amputations (5–24% within 6–18 months) and frequent relapses (40% within a year). The pathogenesis is caused by tissue ischemia due to macro- and microangiopathy, atherosclerotic arterial occlusion and microcirculation disorders. The low effectiveness of standard therapy and the lack of individual approaches to predicting the duration of remission determine the need to develop personalized treatment methods. Objective. A method has been developed to determine the duration of the clinical effect after treatment with an oxygen-helium mixture in patients based on quantitative data characterizing the state of the pathological process before the start of therapy using multidimensional linear regression analysis. Materials and methods. A multidimensional linear regression analysis of a number of parameters characterizing the clinical condition of the patient's body in the treatment of patients with diabetes mellitus, chronic obliterating diseases of the arteries of the lower extremities, and trophic ulcers was performed. The study was conducted using clinical data from 50 patients. Results. A reliable range of indicators was obtained (diastolic blood pressure, LDL (mmol/L), duration of the disease (year), intermittent claudication (m), body temperature in degrees Celsius, UO (ml), height (cm), HDL (mmol/l), cholesterol (mmol/l), affecting the results ongoing therapy. A method for calculating the duration of remission in a particular patient has been developed. The results obtained will improve the quality of care and the correctness of prescribing combination therapy, which in turn will reduce the frequency of surgical procedures. Conclusion. A methodology has been developed for determining the timing of repeated oxygen-helium therapy courses.