Components of the metabolic syndrome at patients with the multifocal atherosclerosis

The article is devoted to studying of components of a metabolic syndrome at patients with multifocal atherosclerosis (MFA). Changes of lipid's, carbohydrate's metabolism parameters, markers of a system inflammation and oxidizing stress are analyzed at patients with MFA, including atherosclerotic damage in various arterial pools (carotid, coronary, iliac-femoral) and it's combinations. Materials and methods of research included the analysis of the clinic and laboratory data at 84 patients with a peripheral and multifocal atherosclerosis. It is established, that at a peripheral atherosclerosis of the main arteries of a leg (AMAL) from components of metabolic syndrome (MS) most frequently observed hyperthreeglyceridemia without obesity. Arterial hypertension and hyperthreeglyceridemia observed at MFA, including carotid arteries damage; obesity and hypercholesterolemia were at patients with stenosis / occlusion of coronary and carotid arteries without atherosclerosis in iliac-femoral vessels. Presence of full cluster of MS observed in 60 % of cases at patients with damage of 3 arterial pools, whereas at patients with AMAL ( damage of 1 arterial pool) it was only in 30 % of cases, that half is less, than at MFA. It specifies the high importance of adverse influence of MS components to MFA progression. It was established, MFA, including carotid and coronary arteries it is accompanied by a high level of oxidizing stress, probably, due to the high sensitivity of brain and heart tissues to hypoxia and vulnerability from toxic effects of reactive oxygen species. At patients with coronary and carotids atherosclerosis the oxidizing stress was closely connected to an inflammation: correlation between C-reactive protein and malondialdehyde levels has made (r = 82, p > 0,05). For MFA, including coronary arteries damage the prevalence of oxidizing stress was established, at MFA with AMAL the inflammation was more expressed. Inflammation and oxidizing stress are factors of development and progressing of MFA.