Psychoemotional disorders and endothelial disfunction in cardiovascular diseases associated with atherosclerosis

The results of clinical and epidemiological studies indicate a high risk of cardiovascular complications in the psychoemotional stress. The prevalence of depressive disorders among patients with pathology of the cardiovascular system is much higher than for other forms of somatic pathology. Anxiety-depressive disorders are independent risk factors for coronary heart disease and arterial hypertension. The study showed correlations between the psychoemotional factors, abnormal endothelial function, and the development of myocardial ischemia. Mental stress leads to activation of the hypothalamic-pituitary-adrenal axis, sympathoadrenal system, and hypersecretion of proinflammatory cytokines contributing to the development of endothelial dysfunction and atherosclerosis, increasing the frequency of severe complications of the disease, including myocardial infarction, and worsening the quality of life of patients.