Радиационный дерматит: современные подходы к лечению. Обзор

Автор: Попова Н.Р., Сорокина С.С.

Журнал: Радиация и риск (Бюллетень Национального радиационно-эпидемиологического регистра) @radiation-and-risk

Статья в выпуске: 3 т.33, 2024 года.

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В настоящее время установлено, что радиационно-индуцированный дерматит является осложнением у 85-95% пациентов, проходящих курс стандартной лучевой терапии. Несмотря на то, что патогенез радиационного дерматита достаточно хорошо изучен, установлены факторы, влияющие на тяжесть его протекания, а также продемонстрированы его отличительные особенности по сравнению с термическим и химическим ожогами, профилактика и лечение радиационного дерматита остаются нерешённой проблемой, приводящей к снижению качества жизни пациентов и различным отдалённым осложнениям. На сегодняшний день в качестве профилактических мер в клинической медицине рекомендуются гигиенические процедуры, а именно: ежедневное поддержание кожи в чистоте, нанесение увлажняющего крема, ношение одежды из мягких тканей, избегание перепадов температур, защита от прямых солнечных лучей. Кроме того, применяется ряд средств, используемых для лечения других форм кожных поражений - увлажняющие и противовоспалительные мази и повязки. Эти процедуры способствуют частичному улучшению качества жизни пациента, однако, не оказывают терапевтического влияния на первичные клеточно-молекулярные причины развития радиационного дерматита. Существует несколько потенциально более эффективных методов лечения, таких как таргетная генная и клеточная терапии, биоактиваторы, ряд физических методов и нанокомпозиты. В своей работе мы рассмотрели современные достижения в области лечения радиационного дерматита, уделив особое внимание перспективам использования нанобиотехнологических препаратов, применение которых активно изучается как в экспериментальных, так и в медицинских исследованиях.

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Радиационный дерматит, фиброз, воспаление, хронический окислительный стресс, средства местного применения, физическая терапия, биоактиваторы, таргетная генная терапия, клеточная терапия, нанокомпозиты, лучевая терапия

Короткий адрес: https://sciup.org/170206297

IDR: 170206297 | DOI: 10.21870/0131-3878-2024-33-3-80-97

Список литературы Радиационный дерматит: современные подходы к лечению. Обзор

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