Microsatellite-unstable colorectal cancer in elderly patients: clinical features and the role of immunodeficiency

Автор: Pashkov Denis V., Venina Ajgul R., Ivantsov Alexandr O., Yanus Grigory A., Raskin Grigory A., Imyanitov Evgeny N., Kubrina Snezhana E., Mikushina Anna D., Manikhas Georgiy M., Ponomareva Elena V., Dzidzava Ilya I., Lyevleva Aglaya G.

Журнал: Сибирский онкологический журнал @siboncoj

Рубрика: Клинические исследования

Статья в выпуске: 1 т.19, 2020 года.

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Background. Tumors demonstrating the phenomenon of microsatellite instability (MSI) represent a special category of colorectal cancer (CRC). Such neoplasms account for up to 20 % of CRC and are characterized by specific molecular and clinical manifestations, including high immunogenicity and sensitivity to immunotherapy. MSI phenotype occurs in two different groups of patients: young individuals with Lynch syndrome and patients older than 70 years with non-hereditary CRC. We assume that the development of sporadic MSI-positive tumors in elderly patients may be associated with age-dependent decrease in immune defense. The aim of the study was to investigate clinical and morphological characteristics in elderly patients with MSI-positive colorectal cancer. Material and Methods. MSI status and mutations in the BRAF gene were tested in a group of 384 CRC patients older than 65 years by PCR-based techniques. A comparative analysis of clinico-pathological features was further conducted in the groups of 23 MSI-positive and 34 MSI-negative CRC cases. Results. MSI-positive phenotype was associated with the proximal tumor location, low degree of differentiation and the presence of the mucinous component in the tumor (p function show_eabstract() { $('#eabstract1').hide(); $('#eabstract2').show(); $('#eabstract_expand').hide(); }

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Colorectal cancer, microsatellite instability, mutation, rhesus antigen

Короткий адрес: https://sciup.org/140254319

IDR: 140254319   |   DOI: 10.21294/1814-4861-2020-19-1-31-39

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