Disorders of homeostasis and disturbance of the functional state of the liver with different severity of mechanical jaundice

A study of 40 operated patients with mechanical jaundice (MJ) of varying severity of non-tumor origin was conducted. Group I (n=20) - mild severity of MJ; Group II (n=20) - severe type of MJ. The assessment of the severity of endogenous intoxication, microcirculatory changes and hemostatic disorders was carried out. It was found that in the early postoperative period of mechanical jaundice, the development of endogenous intoxication, microcirculatory changes and hemostatic disorders are recorded, which are directly related to hepatodepression. The severity of homeostasis disorders and liver damage are associated with the severity of the disease. In the initial stages of severe obstructive jaundice, there is a high tolerance to the therapy, which is the basis for improving treatment regimens.