Редкие злокачественные опухоли вульвы: клиника, диагностика, подходы к лечению
Автор: Саевец В.В., Ростовцев Д.М., Мухин А.А., Шаманова А.Ю., Кузьмин Н.К., Таратонов А.В., Ярина Л.В.
Журнал: Злокачественные опухоли @malignanttumors
Статья в выпуске: 3S1 т.13, 2023 года.
Бесплатный доступ
Рак вульвы (РВ) является редким злокачественным новообразованием среди женщин, доля которого не превышает 4 % от всех онкологических заболеваний. Случаи же меланомы, саркомы, герминогенных и себацейцных гистологических подтипов РВ встречается крайне редко. Мы обобщили свой опыт и других авторов о клинике, диагностике и подходе к лечению редких злокачественных новообразованиях РВ.
Рак вульвы, меланома вульвы, саркома вульвы, себацейная карцинома вульвы, герминогенные опухоли вульвы, редкие опухоли
Короткий адрес: https://sciup.org/140302073
IDR: 140302073 | DOI: 10.18027/2224-5057-2023-13-3s1-32-39
Список литературы Редкие злокачественные опухоли вульвы: клиника, диагностика, подходы к лечению
- Bethesda M. SEER Cancer Statistics Factsheets : Vulvar Cancer // Tamil Nadu : NIH . - 2021.
- Злокачественные новообразования в России в 2021 году (заболеваемость и смертность). Под ред. А.Д. Каприна, В.В. Старинского, Г.В. Петровой. М., 2022.
- Oonk M. H. M. et al. European Society of Gynaecological Oncology Guidelines for the Management of Patients with Vulvar Cancer-Update 2023 // International Journal of Gynecologic Cancer. - 2023. - V. 33. - №. 7.
- Vulvar Cancer, Version 1.2023, NCCN Clinical Practice Guidelines in Oncology https://www.nccn.org/professionals/physician_gls/pdf/vulvar.pdf.
- Sugiyama V. E. et al. Vulvar melanoma : a multivariable analysis of 644 patients // Obstetrics & Gynecology. - 2007. - V. 110. - №. 2. Part 1. - P. 296-301.
- Moxley K. M. et al. Malignant melanoma of the vulva : an extension of cutaneous melanoma? // Gynecologic oncology. - 2011. - V. 122 . - №. 3 . - P. 612-617.
- Mehra T. et al. Primary localization and tumor thickness as prognostic factors of survival in patients with mucosal melanoma // PLoS One. - 2014 . - V. 9 . - №. 11 . - P. e112535.
- Leitao M. M. et al. Gynecologic Cancer InterGroup (GCIG) consensus review for vulvovaginal melanomas // International Journal of Gynecologic Cancer. - 2014 . - V. 24. - №. Supp 3.
- Hassanein A. M. et al. Malignant melanoma associated with lichen sclerosus in the vulva of a 10-year-old // Pediatric dermatology. - 2004. - V. 21. - №. 4. - P. 473-476.
- ACS. American Cancer Society-Key Statistic for Melanoma Skin Cancer. Available online: https://www.cancer.org/cancer/melanoma-skin-cancer/about/key-statistics (accessed on 21 May 2022).
- Kibbi N., Kluger H., Choi J. N. Melanoma : clinical presentations // Melanoma. - 2016 . - P. 107-129.
- Swetter S. M. et al. NCCN Guidelines® insights : melanoma : cutaneous, version 2.2021 : featured updates to the NCCN guidelines // Journal of the National Comprehensive Cancer Network . - 2021. - V. 19 . - №. 4. - P. 364-376.
- Stang A. et al. Population-based incidence rates of malignant melanoma of the vulva in Germany // Gynecologic oncology. - 2005 . - V. 96. - №. 1 . - P. 216-221.
- You J. S., Jones P. A. Cancer genetics and epigenetics : two sides of the same coin? // Cancer cell. - 2012. - V. 22. - №. 1. - P. 9-20.
- Dobrică E. C. et al. Vulvar and vaginal melanomas-the darker shades of gynecological cancers // Biomedicines. - 2021 . - V. 9 . - №. 7.- P. 758.
- Heinzelmann-Schwarz V. A. et al. A clinicopathological review of 33 patients with vulvar melanoma identifies c-KIT as a prognostic marker // International journal of molecular medicine. - 2014. - V. 33. - №. 4. - P. 784-794.
- Paolino G. et al. Vitamin D receptor immunohistochemistry variability in sun-exposed and non-sun-exposed melanomas // Melanoma Research . - 2017. - V. 27. - №. 1. - P. 17-23.
- Tseng D. et al. Oncogenic mutations in melanomas and benign melanocytic nevi of the female genital tract // Journal of the American Academy of Dermatology. - 2014. - V. 71 . - №. 2 . - P. 229-236.
- Jiveskog S. et al. N-ras mutations are common in melanomas from sun-exposed skin of humans but rare in mucosal membranes or unexposed skin // Journal of investigative dermatology. - 1998. - V. 111 . - №. 5. - P. 757-761.
- Torres-Cabala C. A. et al. Correlation between KIT expression and KIT mutation in melanoma : a study of 173 cases with emphasis on the acral-lentiginous / mucosal type // Modern pathology. - 2009. - V. 22. - №. 11 .- P. 1446-1456.
- Omholt K. et al. KIT pathway alterations in mucosal melanomas of the vulva and other sites // Clinical cancer research. - 2011. - V. 17. - №. 12 . - P. 3933-3942.
- Schoenewolf N. L. et al. Sinonasal, genital and acrolentiginous melanomas show distinct characteristics of KIT expression and mutations // European journal of cancer. - 2012. - V. 48 .- №. 12. - P. 1842-1852.
- Hou J. Y. et al. Vulvar and vaginal melanoma : a unique subclass of mucosal melanoma based on a comprehensive molecular analysis of 51 cases compared with 2253 cases of nongynecologic melanoma // Cancer. - 2017. - V. 123 . - №. 8 . - P. 1333-1344.
- Wylomanski S. et al. BRAF mutations might be more common than supposed in vulvar melanomas // Experimental dermatology. - 2018 . - V. 27. - №. 2 . - P. 210-213.
- Saleh B. et al. Frequent PD-L1 expression in malignant melanomas of the vulva // International Journal of Gynecological Pathology. - 2018 .- V. 37. - №. 5 . - P. 477-481.
- Randic T. et al. NRAS mutant melanoma : Towards better therapies // Cancer treatment reviews. - 2021. V. 99. - P. 102238.
- Tseng D. et al. Oncogenic mutations in melanomas and benign melanocytic nevi of the female genital tract // Journal of the American Academy of Dermatology. - 2014 . - V. 71. - №. 2. - P. 229-236.
- Grill C., Larue L. NRAS, NRAS, which mutation is fairest of them all? // Journal of Investigative Dermatology. - 2016. - V. 136. - №. 10. - P. 1936-1938.
- Ragnarsson-Olding B. K. Primary malignant melanoma of the vulva an aggressive tumor for modeling the genesis of non-UV light-associated melanomas // Acta Oncologica. - 2004. - V. 43. - №. 5. - P. 421-435.
- Murzaku E. C. et al. Vulvar nevi, melanosis, and melanoma : an epidemiologic, clinical, and histopathologic review // Journal of the American Academy of Dermatology. - 2014. - V. 71. - №. 6. - P. 1241-1249.
- Wohlmuth C., Wohlmuth-Wieser I. Vulvar melanoma : molecular characteristics, diagnosis, surgical management, and medical treatment // American Journal of Clinical Dermatology. - 2021 . - V. 22 .- №. 5 . - P. 639-651.
- An J. et al. Primary malignant amelanotic melanoma of the female genital tract : report of two cases and review of literature // Melanoma research. - 2009. - V. 19 . - №. 4. - P. 267-270.
- Baderca F. et al. Amelanotic vulvar melanoma : case report and review of the literature // Rom J Morphol Embryol.- 2008. - P. 49. - №. 2. - P. 219-228.
- Ragnarsson-Olding B. K. et al. Malignant melanoma of the vulva in a nationwide, 25-year study of 219 Swedish females : clinical observations and histopathologic features // Cancer : Interdisciplinary International Journal of the American Cancer Society. - 1999. - V. 86. - №. 7. - P. 1273-1284.
- Brenn T. Atypical genital nevus // Archives of Pathology & Laboratory Medicine. - 2011 . - V. 135. - №. 3. - P. 317-320.
- Ditto A. et al. Surgical management and prognostic factors of vulvovaginal melanoma // Journal of lower genital tract disease. - 2016. - V. 20. - №. 3 . - P. e24-e29.
- Lotem M. et al. Mucosal melanoma of the female genital tract is a multifocal disorder // Gynecologic oncology . - 2003 .- V. 88. - №. 1. - P. 45-50.
- Vitale S. G. et al. Recent trends in surgical and reconstructive management of vulvar cancer : review of literature // Updates in surgery. - 2015. - V. 67. - V. 367-371.
- Gaarenstroom K. N. et al. Postoperative complications after vulvectomy and inguinofemoral lymphadenectomy using separate groin incisions // International Journal of Gynecologic Cancer. - 2003. - V. 13 . - №. 4.
- Gadducci A. et al. Melanoma of the lower genital tract : Prognostic factors and treatment modalities // Gynecologic Oncology. - 2018 . - V. 150. - №. 1. - P. 180-189.
- Boer F. L. et al. Vulvar malignant melanoma : Pathogenesis, clinical behaviour and management : Review of the literature // Cancer Treatment Reviews. - 2019 . - V. 73 . - P. 91-103.
- Smith H. G. et al. Ano-uro-genital mucosal melanoma UK national guidelines // European Journal of Cancer. - 2020 . - V. 135 . - P. 22-30.
- Iacoponi S. et al. Prognostic factors of recurrence and survival in vulvar melanoma : subgroup analysis of the VULvar CANcer study // International Journal of Gynecologic Cancer. - 2016. - V. 26. - №. 7.
- Nagarajan P. et al. Tumor thickness and mitotic rate robustly predict melanoma-specific survival in patients with primary vulvar melanoma : a retrospective review of 100 cases // Clinical Cancer Research. - 2017 . - V. 23. - №. 8 . - P. 2093-2104.
- Sanchez A. et al. Primary genitourinary melanoma : epidemiology and disease-specific survival in a large population-based cohort // Urologic Oncology : Seminars and Original Investigations. - Elsevier, 2016. - V. 34 .- №. 4 . - P. 166. e7-166. e14.
- Scheistrøen M. et al. Malignant melanoma of the vulva. Evaluation of prognostic factors with emphasis on DNA ploidy in 75 patients // Cancer. - 1995 . - V. 75 . - №. 1. - P. 72-80.
- Raspagliesi F. et al. Prognostic indicators in melanoma of the vulva // Annals of surgical oncology . - 2000. - V. 7 . - P. 738-742.
- Irvin Jr W. P. et al. Vulvar melanoma : a retrospective analysis and literature review // Gynecologic Oncology. - 2001. - V. 83 .- №. 3 . - P. 457-465.
- Chokoeva A. A. et al. Vulvar sarcomas : short guideline for histopathological recognition and clinical management. Part 2 // International Journal of Immunopathology and Pharmacology. - 2015 .- V. 28. - №. 2. - P. 178-186.
- Chokoeva A. A. et al. Vulvar sarcomas : short guideline for histopathological recognition and clinical management. Part 1 // International journal of immunopathology and pharmacology. - 2015 .- V. 28 . - №. 2 . - P. 168-177.
- Nucci M. R., Fletcher C. D. M. Liposarcoma (Atypical Lipomatous Tumors) of the Vulva A Clinicopathologic Study of Six Cases // International journal of gynecological pathology. - 1998 . - V. 17 .- №. 1 .- P. 17-23.
- Magné N. et al. Sarcoma of vulva, vagina and ovary // Best Practice & Research Clinical Obstetrics & Gynaecology. - 2011 . - V. 25 . - №. 6 .- P. 797-801.
- Johnson S. et al. Vulvar sarcoma outcomes by histologic subtype : a Surveillance, Epidemiology, and End Results (SEER) database review // International Journal of Gynecologic Cancer. - 2020 . - V. 30 .- №. 8.
- Nogales F. F., Preda O., Nicolae A. Yolk sac tumours revisited. A review of their many faces and names // Histopathology. - 2012. - Т. 60. - №. 7. - P. 1023-1033.
- JK M. C. K. Heerema-M cKenney A, Rouse RV. Extragonadal germ cell tumors : A review with emphasis on pathologic features, clinical prognostic variables, and differential diagnostic considerations // Adv Anat Pathol. - 2007. - V. 14. - №. 2. - P. 69-92.
- Clement P. B., Young R. H., Scully R. E. Extraovarian pelvic yolk sac tumors // Cancer . - 1988 .- V. 62 .- №. 3 . - P. 620-626.
- Dede M. et al. Extragonadal yolk sac tumor in pelvic localization. A case report and literature review // Gynecologic oncology . - 2004. - V. 92 .- №. 3. - P. 989-991.
- Xu W. et al. Vulvar yolk sac tumor diagnosed during pregnancy, with recurrence during subsequent second pregnancy // Gynecologic Oncology Reports. - 2015. - V. 12. - P. 67.
- Euscher E. D. Unusual presentations of gynecologic tumors : extragonadal yolk sac tumor of the vulva // Archives of pathology & laboratory medicine. - 2017. - V. 141. - №. 2. - P. 293-297.
- Ламоткин И.А. Онкодерматология. [Электронный ресурс] : атлас : учебное пособие . - Эл. изд .- М. : Лаборатория знаний, 2021. Режим доступа: http://client.studmedlib.ru/book/ISBN9785932085561.html.
- Rulon D. B., Helwig E. B. Cutaneous sebaceous neoplasms // Cancer. - 1974 .- V. 33. - №. 1. - P. 82-102.
- Pusiol T., Morichetti D., Zorzi M. G. Sebaceous carcinoma of the vulva : critical approach to grading and review of the literature // Pathologica. - 2011. - V. 103 .- №. 3. - P. 64-67.
- Carlson J. W. et al. Sebaceous carcinoma of the vulva : a case report and review of the literature // Gynecologic oncology. - 1996 . - V. 60. - №. 3. - P. 489-491.
- Thakur B. K. et al. Multifocal sebaceous carcinoma of the vulva // Indian Journal of Dermatology, Venereology and Leprology. - 2017. - V. 83 . - P. 221.
- Sullivan S. A. et al. Sebaceous carcinoma of the vulva : A case report and review of the literature // Gynecologic Oncology Reports. - 2016. - V. 18. - P. 40.
- Yam P. et al. M363 SEBACEOUS CARCINOMA OF THE VULVA A RARE TUMOR OF VULVA // International Journal of Gynaecology and Obstetrics. - 2012. - V. 119 . - №. 3 . - P. 6.
- Escalonilla P. et al. Sebaceous carcinoma of the vulva // The American journal of dermatopathology. - 1999. - V. 21. - №. 5 .- P. 468.
- Kawamoto M. et al. Sebaceous carcinoma of the vulva // Pathology international. - 1995 .- V. 45 . - №. 10. - P. 767-773.
- Jacobs D. M., Sandles L. G., Leboit P. E. Sebaceous carcinoma arising from Bowen’s disease of the vulva // Archives of dermatology .- 1986 .- V. 122. - №. 10. - P. 1191-1193.
- Ikuse S. A case of sebaceous carcinoma // Jpn. J. Dermatol . - 1976 . - V. 86 .- P. 783.
- Alharthi H. et al. Sebaceous carcinoma of the vulva : a case report and review of the literature // Avicenna Journal of Medicine .- 2021. - V. 11. - №. 01. - P. 49-53.
- Yamamoto A. et al. Sebaceous carcinoma of the vulva treated with sentinel lymph node biopsy : a case report and literature review // International Cancer Conference Journal .- Singapore : Springer Singapore, 2021. - V. 10. - №. 3. - P. 239-243.
- Khan Z. et al. Sebaceous carcinoma of the vulva // BJOG (Oxford. Print). - 2003. - Т. 110. - №. 2. - С. 227-228.