Roentgen-and-morphological characteristics of shaft tibial fracture consolidation under intramedullary osteosynthesis using wires with hydroxyapatite coating

Purpose. Quantitative evaluation of the roentgen-and-morphological characteristics of long bone shaft fracture healing experimentally. Material and Methods. Open tibial fracture modeled in dogs experimentally, osteosynthesis using the Ilizarov fixator performed with hydroxyapatite-coated wire intramedullary insertion. A quantitative analysis of fracture consolidation dynamics made using computed tomography methods, and digitized images of X-rays made in two standard views investigated using “DiaMorph” hardware-and-software complex. Results. Fracture consolidation clinically and by X-rays occurred after 3-4 weeks. The density of regenerated bone in the intermediate zone three weeks after osteosynthesis amounted to 37% of the density of contralateral limb cortex, and besides the share of highly mineralized structures in the medullary space increased significantly (р=0.003) more than 5-fold, and that in the zone of cortical plate - 3-fold. Conclusion. The results of the study evidence of a positive effect of intramedullary wires with hydroxyapatite coating on the course and intensity of reparative osteogenesis during the fracture healing and the onset of consolidation within a month. The data allow to recommend this comparatively little-invasive technique of osteoreparation condition optimization for using in complex with other methods of conservative and surgical treatment of bone fractures.