Reproductive function and viability offspring of American minks with different genotypes exposed veterinary drug «Biostil»

On the example of the American mink shown differential effects of mutations affecting the coat color on the administration per os integrated veterinary drug «Biostil». Mutations, which influence on the coat color of fur animals, having pleiotropic effects, have an impact on many vital processes, including reproductive function, leading to a later ovulation and egg implantation embryos and also increasing embryonic mortality. Revealed, that the same dose of «Biostil» provided with the differential impact on minks of different genotypes. In the control groups of minks both Standard (+/+ +/+) and double recessive Sapphire (a/a p/p), Lavender (a/a m/m) obtained by the same rate in the pups output per a female: 4,4±0,4; 4,4±0.5; 4,3±0,5, respectively. In the experimental groups, if stimulation of reproductive function among mink Standard was achieved: 5,2±0.3, then among the mutant Sapphire and Lavender, on the contrary, was inhibition: 3,8±0,6; 2,3±0,5, respectively. In the experimental groups of mutant mink recorded decline in viability and developmental rate of kits: decrease safety in the first 10 days after birth and later periods of eye opening compared with kits coloring Standard (+/+ +/+).