Leptin resistance and diet-induced obesity. Central and peripheral actions of leptin

The article those findings regarding leptin resistance development and the role of this hormone in the development and maintenance of an obese state. An overview of the research findings on the effect of the impaired leptin action on adipose tissue, liver, skeletal muscle and intestinal function and the concomitant with diet-induced obesity. Discusses the role of some inflammatory mediators involved in the development of obesity and leptin resistance.