The resistance to progressive normobaric hypoxia in anesthetized rats

The study have shown that the rapid rise of acute hypoxia to 6 % O 2 and related hypocapnia does not cause significant changes in external respiration system, cardiovascular parameters and reactive capability of the respiratory systems in anesthetized rats. Further reduction of oxygen in the inspired gas mixture leads to irreversible damage, which manifests a sharp decrease in blood pressure, critical care and apnea. In the genesis of severe hypoxia major role play a metabolism shifts, leading to changes in the activity of the central and peripheral chemoreceptors and depression of vasomotor and respiratory center function.