The results of anticoagulant therapy with inhibitors of the x factor of coagulation of deep vein thrombosis against the background of chronic obliterating diseases of the arteries of the lower extremities in the elderly and senile

The aim is to compare the efficacy and safety of rivaroxaban and apixaban in the treatment of deep vein thrombosis of the lower extremities in elderly and senile people suffering from chronic obliterating atherosclerosis of the arteries of the lower extremities.Materials and methods. The results of treatment of 60 elderly and senile patients suffering from obliterating atherosclerosis of the arteries of the lower extremities, who developed deep vein thrombosis, were retrospectively studied. The patients were divided into 2 statistically homogeneous groups of 30 people each. The intergroup difference was the choice of the drug for long-term anticoagulant therapy. In the first group, anticoagulant therapy was performed with apixaban, and in the second group with rivaroxaban. The results of treatment were evaluated after one year by a control ultrasound and clinical examination to determine the degree of restoration of the deep vein lumen and the severity of venous outflow disorders. The frequency of hemorrhagic syndrome was recorded.Results. After one year, effective recanalization (complete +partial) in the first group occurred in 24 (80%), and in the second - in 29 (96.7%), occlusion developed in 6 (20%) and 1 (3.3%) patients, respectively. Good one-year clinical results (degree of impairment is weak or absent) 18 (60%) patients were registered in the first group, and 24 (80%) patients in the second group. Poor results (the degree of impairment is medium and severe) were found in the first group of u12 (40%).and in the second group -in 6 (20%) patients. Hemorrhagic complications of anticoagulant therapy developed in 8 (13.2%) patients equally in both groups.Conclusion. Revaroxaban is more effective than apixaban, and there are no differences between the drugs in terms of safety