Outcomes of search for biomarkers of schizophrenia

As a result of complex study of a number of parameters of blood serum of schizophrenic patients a reliable elevation of concentration of glutamate, cortisol, glial protein S100B, antibodies to myelin basic protein, nuclear fraction of middle mass molecules (MMM), DNA-hydrolyzing activity of IgG is revealed against the background of substantial reduction of neurosteroids of dehydroepiandrosterone (DHEA) and dehydroepiandrosterone sulfate (DHEAS), aromatic fraction of MMM, antibodies (AB) to singlestranded DNA, oxidized glutathione. Brain neurotrophic factor and activity of DNA-hydrolyzing antibodies show positive correlation with leading positive symptoms in patients with schizophrenia. Factors such as leading negative symptoms and length of disease more than 3 years, on the contrary, cause in these patients unidirectional alterations which are expressed in lowering the concentration of steroid neuroprotector DHEAS, oxidized glutathione and AB to single-stranded DNA. With use of proteomic analysis four non-specific proteins are revealed which characterize pathogenetic alterations in schizophrenia.