Role of adhesion molecules VCAM-1 and VE-cadherin in endothelium dysfunction development at hemorrhagic fever with renal syndrome

The research goal is to determine the changes in concentration of both sVCA M-1 and VE-cadherin in blood serum of patients suffered from hemorrhagic fever with renal syndrome (HF RS). 87 patients aged 15 - 65 were examined. Concentrations of both sVCA M-1 and VE- cadherin in blood serum by means of Bender MedSystems (Austria) EL ISA test were determined. It was shown that in both medium severe and severe forms of HF RS statistically the significant rise of sVCA M-1 concentration in blood with high indices in oliguric period took place. Complicated form was characterized by high indices of sVCA M-1 level in fever period, extremely decreasing in concentration in oliguric period and tendency to normalizing in clinical convalescence period. VE-cadherin level in blood was predominantly lower than control in all the observed groups with the exception of fever period in group with medium severe disease form. Negative correlation of normal intensity between adhesion molecules levels in blood was revealed. In conclusion it is necessary to point out that high VCA M-1 expression by endotheliocytes evidences the development of an adhesion form of endothelial dysfunction, low VE-cadherin production in a base for development of angiogenic form of endothelial dysfunction and changes in expression of these adhesion molecules that have adaptive metabolic response to macroorganism of HF RS pathogenic action.