The role of an agonist of 5-HT2 serotonin receptors in the lability of the heart rate

This work is devoted to the study of the mobility of heart rate indicators of laboratory white rats of various levels of fitness under the influence of 2 consecutive injections of a 5-HT2 serotonin receptor agonist. We studied 2 groups of 70-day-old rats with different levels of fitness. The first group of rats (control) had unlimited motor activity. The second group (experimental) was exposed to active swimming training. The regulatory role of the serotonin receptor agonist in the labiality of rat heart rate indicators was studied. In 70-day-old rats, the highest variability in the direction of decreasing heart rate indicators in absolute values is recorded when they are injected with a 5-HT2 serotonin receptor agonist drug. Initially, the heart rate indicators in swimming-trained rats, at rest before injection, were lower than those in animals that were constantly in conditions of unlimited motor activity. Under the influence of an agonist of 5-HT2 serotonin receptors in rats, there is a decrease in heart rate indicators and in the group of trained rats this regulatory effect is less pronounced, compared with rats who had no restrictions in motor activity.