Роль аргинин-вазопрессина в регуляции активности нейронов циркадианных часов супрахиазматического ядра гипоталамуса

Роль аргинин-вазопрессина в регуляции активности нейронов циркадианных часов супрахиазматического ядра гипоталамуса

Автор: Ткачева М.А., Инюшкина Е.М., Карян С.Д., Инюшкин А.Н.

Журнал: Ульяновский медико-биологический журнал @medbio-ulsu

Рубрика: Физиология

Статья в выпуске: 1, 2018 года.

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Аргинин-вазопрессин является наиболее распространенным нейропептидом в нейронах супрахиазматического ядра млекопитающих, выполняющим роль главного циркадианного осциллятора. Существует суточный ритм количества вазопрессинергических нейронов в супрахиазматическом ядре с ростом в дневные часы и увеличением продукции вазопрессина в утренние часы. Этот ритм важен для циклической суточной регуляции активности гормональных гипоталамогипофизарно-надпочечниковой и гипоталамо-гипофизарно-гонадальной осей, а также тонуса вегетативной нервной системы. Вазопрессинергические нейроны супрахиазматического ядра оказались вовлеченными в патогенез ряда заболеваний, в частности первичной артериальной гипертензии, депрессивных состояний.Цель исследования состояла в изучении влияния аргинин-вазопрессина на параметры электрической активности нейронов циркадианного осциллятора.Материалы и методы. Эксперименты выполнены in vitro на переживающих срезах гипоталамуса крыс-самцов линии Вистар. С помощью электрофизиологической техники микроэлектродной регистрации изучали влияние аппликаций 20 нМ вазопрессина в перфузионный раствор на пара метры спайковой активности нейронов супрахиазматического ядра...

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Вазопрессин, супрахиазматическое ядро гипоталамуса, реабсорбция, имунно- цитохимия, осморецепторы, биологические ритмы, спайковое кодирование информации

Короткий адрес: https://sciup.org/14113332

IDR: 14113332   |   DOI: 10.23648/UMBJ.2018.29.11371

Список литературы Роль аргинин-вазопрессина в регуляции активности нейронов циркадианных часов супрахиазматического ядра гипоталамуса

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