Role of arginine-vazopressin in regulation of circadian rhythmneurons of suprachiasmatic hypothalamus nucleus

Arginine-vasopressin is the most common neuropeptide in neurons of the suprachiasmatic nucleus of mammals, which acts as the main circadian oscillator. Vasopressinergic neurons of the suprachiasmatic nucleus undergo a daily rhythm: they grow in the daytime, but vasopressin production increases in the morning. This rhythm is important for cyclical daily regulation of hormonal hypothalamic-pituitaryadrenal and hypothalamic-pituitary-gonadal axes, and for the autonomic nervous system tonus. Vaso- pressinergic neurons of the suprachiasmatic nucleus are involved in the pathogenesis of various diseases, namely, arterial hypertension, and depressive states.The objective of the study was to analyze the effect of arginine-vasopressin on neuronal electrical activity in a circadian oscillator.Materials and Methods. The experiments were conducted in vitro on dead-end sections of male Wistar rats’ hypothalamus. Electrophysiological method for microelectrode registration was used to study the effect of 20 nM vasopressin applications in the perfused solution on the parameters of the spike activity of suprachiasmatic nucleus neurons...