Роль астроцитов в нейровоспалении (обзор)

Автор: Мордовина А.И., Руденко Е.Е., Демура Т.А.

Журнал: Саратовский научно-медицинский журнал @ssmj

Статья в выпуске: 1 т.19, 2023 года.

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Цель: представить результаты исследований роли астроцитов в нейровоспалении, а также взаимодействий астроглиоцитов с другими глиальными клетками и нейронами в контексте нейровоспаления. Найдены 63 научные работы с использованием для поиска баз данных Cochrane Library, PubMed по запросам: «астроциты и нейровоспаление», «реактивные астроциты», «нейроглия и нейровоспаление». Для обзора отобрано 45 источников. Временной интервал анализируемой литературы: 2000-2020 гг. Сделан вывод о двойственности роли астроцитов в нейровоспалении. Эти клетки оказывают как защитный, так и разрушительный эффект. Важно понимать, что деятельность реактивных астроцитов зависит от их топографического расположения и микроокружения, а также медиаторов, которые выделяются клетками резидентами и нерезидентами центральной нервной системы (ЦНС). Знания о регуляции астроцитарных эффектов необходимы для реализации терапевтического потенциала астроглиоцитов.

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Астроциты, нейровоспаление, нейроглия

Короткий адрес: https://sciup.org/149143900

IDR: 149143900 | DOI: 10.15275/ssmj1901089

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