Role of сAMP, cGMP, NO-synthase, КАТP-channels and proteinkinase C in development of cardioprotective effect of cannabinoid receptor agonist HU-210

The study showed that activation of CB1 and CB2 receptors with selective agonist HU-210 at a final concentration of 0.1·10-3 and 1.0·10-3 mM improved myocardial tolerance to total ischemia and reperfusion. Data suggested that intracellular mechanism of cardioprotective effect of selective agonist HU"210 was mediated through activation of KATP"channels and PKC and was not associated with changes in the activity of NO"synthase and the levels of cyclic nucleotides