Role of cytokines of the IL-1 family in implantation and development of induced pregnancy

Cytokines of the interlekin-1 (IL-1) family play an important role in the regulation of the immune response, including by inducing the synthesis of other cytokines, chemokines, and matrix metalloproteinases. All components of IL-1 are found in the endometrium throughout the entire menstrual cycle. endometrial factors Stimulate the secretion of IL-1 by the embryo, which contributes to the formation of the relationship between the mother's endometrium and the embryo before implantation. The article presents the results of an analysis of modern literature sources devoted to the role of IL-1α, IL-1β, IL-1Rа in the process of implantation and the development of spontaneous and induced pregnancy.