The role of cytokines in the regulation of functional activity and populational status of mast cells during allergic inflammation in bronchial tree

The aim was to study a role of cytokines of heterogeneous populations of mast cells during allergic inflammation in patients with various clinical forms of bronchial asthma. There was a try to estimate morphofunctional status of mast cells in biopsy of mucous membrane of bronchial tubes and in bronchial washouts of 30 patients - the maintenance of interleukin-4, interleukin-8, interferon, the tumour necrosis factor. Disbalance development of the basic immunopathologition molecules (interleukin-4, interferon γ) leads to a heterogeneous orientation of atopition inflammations in a mucous membrane of bronchial tubes and is associated with development of various clinical variants of a bronchial asthma. More intensive accumulation and degranulation of the corpulent cells, developing during the activity of interleukin-8 and tumours necrosis factor, aggravates an allergic pattern of an inflammation and leads to heavy current of asthma. As the research has shown, inflammatory changes in bronchial system during bronchial asthma, represent a complex process mediated by interaction of cytokines and basic effectors of cells.