Роль генов семейства Argonaute в эффектах активатора РНК-интерференции эноксацина на продолжительность жизни Drosophila melanogaster

Автор: Пакшина Н.Р., Яковлева Д.В., Уляшева Н.С., Прошкина Е.Н., Москалев А.А.

Журнал: Известия Коми научного центра УрО РАН @izvestia-komisc

Статья в выпуске: 6 (64), 2023 года.

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Эпигенетические механизмы играют ведущую роль в регуляции генной экспрессии и координации биологических процессов, влияя на скорость старения и продолжительность жизни организма. Важную роль в реализации этих механизмов играют малые РНК, которые подавляют активность своих мишеней путем РНК-интерференции и обеспечивают противовирусную защиту. Эноксацин является уникальным индуктором факторов РНК-интерференции с потенциальной геропротекторной активностью. Установлено, что его эффекты опосредованы микроРНК, но возможно участие и других видов некодирующих РНК. В данном исследовании мы изучили влияние эноксацина на продолжительность жизни Drosophila melanogaster и впервые проанализировали вклад в его эффект генов семейства Argonaute, которые специфично обеспечивают биогенез и функционирование микроРНК, киРНК и пивиРНК.

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Малые рнк, рнк-интерференция, эноксацин, продолжительность жизни, старение, гены argonaute, drosophila melanogaster

Короткий адрес: https://sciup.org/149143620

IDR: 149143620 | DOI: 10.19110/1994-5655-2023-6-103-114

Список литературы Роль генов семейства Argonaute в эффектах активатора РНК-интерференции эноксацина на продолжительность жизни Drosophila melanogaster

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