Role of human chorionic gonadotropin in differentiation of interleukin-17-producing tlymphocytes helpers

Effects of human chorionic gonadotropin (hCG) on differentiation of interleukin (IL)-17-producing lymphocytes were analyzed. It was revealed that at thymic stage of differentiation this hormone did not affect the amount of Th17 (CD4+CD161+) precursors and Th17 (CD4+CD161+IL17A+) generation; however in low concentration (10 IU/ml) it raised the number of CD4+IL17A+-thymocytes. At the level of peripheral Th17 this hormone was found to reduce the quantity of CD4+ROR-1+- and CD4+ROR- t+IL-17А+-lymphocytes. Consequently hCG is an effective Th-17-lymphocyte modulator while rendering multidirectional effects at thymic and post-thymic stages of differentiation.