Role of IL-1B. IL-6 and prostaglandines in regulation of functional activity of lymphocytes under opioid peptides

It was determined that in non-fractionated cell culture beta-endorphin promoted the IL-1?? production and inhibited IL-8 in LPS presence while not influencing the TNF-?? and IL-6 production. Slight stimulating effect in leukocyte culture was exerted by peptide to IL-1?? spontaneous production. It is shown that beta-endorphin is able to render both mediated and direct effect on lymphoid cell functional activity.