The role of immune proteasomes in the mechanisms of lymphatic metastasis in non-small cell lung cancer

Автор: Sidenko E.A., Kakurina G.V., Yunusova N.V., Korshunov D.A., Mokh A.A., Rodionov E.O., Miller S.V., Kondakova I.V.

Журнал: Сибирский онкологический журнал @siboncoj

Рубрика: Обзоры

Статья в выпуске: 4 т.24, 2025 года.

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Objective. This review aimed to study the role of immune proteasomes in the mechanisms of lymphatic metastasis in non-small cell lung cancer (nsClC). Material and Methods. The review’s literature search was conducted using the Medline, Cochrane library, and elibrary databases, with a focus on publications from the last decade. Results. The concepts of molecular mechanisms of lymphatic metastasis in lung cancer, including the role of immune proteasomes in the development of nsClC were presented. Studies indicating the involvement of proteasomes in the regulation of angiogenesis and cell locomotion processes were found. An increase in the expression of the PSMB8 and PSMB9 genes encoding immunoproteasome subunits in nsClC cell cultures was described. Information that immunoproteasomes could be a therapeutic target in cisplatin-resistant lung cancer was presented. Conclusion. The study of the mechanisms of lymphatic metastasis in cancer development remains crucial in cancer research. The data obtained have shown that proteasomes are a promising molecular target and their further study can open new horizons in the fight against cancer.

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Lung cancer, non-small cell lung cancer, immunoproteasome, proteasome, lymphatic metastasis

Короткий адрес: https://sciup.org/140312280

IDR: 140312280   |   УДК: 616.24-006.6-033.2:611-018.98:577.112   |   DOI: 10.21294/1814-4861-2025-24-4-147-154