Role of endothelial dysfunction in the development and progressing of vascular events of 1 type diabetes mellitus in children and teenagers

A study of endothelin 1-21 level in blood serum in patients with I type diabetes mellitus patients was carried out. The analysis of the received data testifies to the diagnostically significant increase in the level of endothelin 1-21 when duration of 1 type diabetes is more than 5 years. When the values of endothelin 1-21 are elevated the frequency of diabetic nephropathy, retinopathy and polyneuropathy development increases compared to patients having normal level of the given hormone. The connection between development and progression of diabetic nephropathy and elevated level of endothelin 1-21 was revealed already at the stage of microalbuminuria with the statistically significant increase at the stage of proteinuria.