Роль кишечной микробиоты в развитии ожирения

Автор: Воловникова В.А., Котрова А.Д., Иванова К.А., Ермоленко Е.И., Шишкин А.Н.

Статья в выпуске: 6, 2019 года.

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Ожирение является глобальной эпидемией современности и имеет серьезные последствия для здоровья, так как является важнейшим фактором риска развития таких хронических заболеваний, как артериальная гипертензия, сахарный диабет 2 типа, дислипидемии, атеросклероз и его осложнения. Изучение факторов риска, патогенетических механизмов, а также поиск новых методов лечения и профилактики данной патологии является актуальной задачей современной медицины. На сегодняшний день известно, что определенную роль в развитии ожирения и ряда метаболических расстройств играют состав и функция микробиоты кишечника. Одним из направлений профилактики раннего возникновения и развития ассоциированных с ожирением заболеваний может быть поддержание нормального состава и коррекция нарушений экосистемы кишечника. В данном обзоре рассмотрены известные на сегодняшний день взаимосвязи изменений состава кишечной микробиоты и ожирения, проанализированы исследования, проведенные с целью оценки состава микробинома кишечника взрослого человека при ожирении. Представлены имеющиеся на сегодняшний день данные по коррекции избыточной массы и ожирения путем воздействия на состав кишечной микробиоты.

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Ожирение, кишечная микробиота, пребиотики, пробиотики, бариатрическая хирургия, трансплантация фекальной микробиоты

Короткий адрес: https://sciup.org/14114593

IDR: 14114593 | DOI: 10.32415/jscientia.2019.06.01

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