The role of cell-intercellular relations in the development of intimal hyperplasia in the internal thoracic artery

Intimal hyperplasia in the internal thoracic artery is a complex cell-extracellular ensemble, in which the leading role is played by smooth muscle cells. The functional state of smooth myocytes and their ability for proliferation, secretory activity with the production of the glycosaminoglycans may cause pathological changes not only in the intima but also in the media of the internal thoracic artery with accumulation of acid mucopolysaccharides. The obtained data can help to justify the use of targeted therapeutic drugs aimed at inhibiting the activity and proliferation of smooth muscle cells that would prevent the occurrence of restenosis after surgical interventions on coronary vessels.