The role of macrophages in regulation of biosynthesis of proteins in cells of Еhrlich carcinoma

The role of peritoneal macrophages of mice with Ehrlich carcinoma in uptake and metabolic degradation of a protein component of high density lipoproteins has been studied. Stimulating effect of cortisol on these processes has been revealed. Differences in spectra of endocellular proteins between tumor-associated macrophages and peritoneal macrophages of healthy mice, in particular, in the level of apolipoprotein E have been shown. Participation of macrophages in the regulation of the protein biosynthesis rate in tumor cells under the influence of high density lipoproteins and cortisol has been shown. Apolipoprotein Е can play a role of a negative feedback in the mechanism of increasing the rate of protein biosynthesis in tumor cells.