Роль маркеров системного воспалительного ответа в послеоперационном периоде. Обзор

Роль маркеров системного воспалительного ответа в послеоперационном периоде. Обзор

Автор: Кубышкин В.А., Самоходская Л.М., Королев Ю.М.

Журнал: Хирургическая практика @spractice

Рубрика: Статьи

Статья в выпуске: 1 (45), 2021 года.

Бесплатный доступ

Несмотря на все достижения современной хирургии количество послеоперационных инфекционных осложнений в мире остается высоким. Их возникновение приводит к удлинению периода госпитализации пациентов, требует применения дополнительных лечебно-диагностических мероприятий, что в конечном итоге ведет к повышению затрат на лечение и значительным финансовым потерям в системе здравоохранения. Поэтому важно выявлять послеоперационные осложнения на ранней стадии, еще до развития выраженных клинических симптомов, предсказывать их возможное развитие у определенной категории пациентов. Для этих целей ученые пытаются использовать различные лабораторные маркеры. В данной работе мы проанализировали как широко известные показатели воспалительного ответа, а именно: С-реактивный белок, альбумин, их соотношение, прокальцитонин и интерлейкин-6, так и относительно новые параметры, которые коллективы исследователей пытаются применить для этих целей: показатели гранулярности и реактивности нейтрофилов, панкреатический каменный белок и панкреатит-ассоциированный белок. Мы постарались собрать наиболее полную информацию, существующую на данный момент, оценить мнения исследователей, выявить противоречия в их работах и попытаться объяснить их причину. В результате оказалось, что даже известные в течение многих лет маркеры воспаления не являются абсолютно специфичными в отношении послеоперационных инфекционных осложнений. Мы пришли к выводу, что большинство из описанных нами лабораторных параметров может быть в той или иной мере использовано в ранней диагностике послеоперационных инфекционных осложнений, однако для получения более полной информации в этой области знаний необходимо проведение новых крупных исследований.

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Послеоперационные осложнения, диагностика, с-реактивный белок, альбумин, отношение с-реактивный белок/альбумин, прокальцитонин, интерлейкин-6, показатель гранулярности нейтрофилов, показатель реактивности нейтрофилов, панкреатический каменный белок, панкреатит-ассоциированный белок

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Короткий адрес: https://sciup.org/142230052

IDR: 142230052   |   DOI: 10.38181/2223-2427-2021-1-30-38

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