Роль микро-РНК при солидных опухолях

Роль микро-РНК при солидных опухолях

Автор: Федянин Михаил Юрьевич, Игнатова Екатерина Олеговна, Тюляндин Сергей Алексеевич

Журнал: Злокачественные опухоли @malignanttumors

Рубрика: Фундаментальная онкология и экспериментальная медицина

Статья в выпуске: 1 (5), 2013 года.

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Последнее десятилетие сопровождается появлением большого количества исследований, посвященных роли малых, не кодирующих белок, молекул РНК (микро-РНК) в канцерогенезе и развитии резистентности к проводимой противоопухолевой терапии. Семейство генов микро-РНК составляет немногим более 1% от всего генома человека, но регулирует экспрессию почти трети всех генов на посттранскрипционном уровне. При нарастающем внимании специалистов к персонализированному подходу в лечении онкологических больных, внедрение знаний по ролимикро-РНК в клинику позволит в будущем индивидуализировать подход в лечении этого сложного контингента пациентов.В этом обзоре приводится информация о номенклатуре и механизмах образования микро-РНК, анализируется взаимосвязь между профилем экспрессии микро-РНК и фенотипом опухоли, а также обсуждается возможное применение микро-РНК в клинической практике.

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Микро-рнк, факторы прогноза, предикторные факторы

Короткий адрес: https://sciup.org/14045443

IDR: 14045443

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