Роль MTOR в репрограммировании опухоль-ассоциированных макрофагов и в канцерогенезе (обзор)

Автор: Мартынова Т.Н., Малышев И.Ю.

Журнал: Саратовский научно-медицинский журнал @ssmj

Статья в выпуске: 1 т.16, 2020 года.

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Макрофаги - гетерогенная популяция клеток, которые дифференцируются в различные функциональные группы в зависимости от полученных сигналов. Агонисты toll-like рецепторов и цитокины воздействуют на соответствующие рецепторы, вызывая изменения метаболизма и экспрессии генов в миелоидных клетках системы врожденного иммунитета. Данные изменения в фагоцитах происходят в процессе их активации, в результате они становятся поляризованными в том или ином направлении, приобретая определенный фенотип. Данные изменения экспрессии генов реализуются в опухолевом микроокружении. mTOR (mammalian target of rapamycin) - серин/треониновая протеинкиназа, которая реагирует на различные стимулы окружения клетки изменением ее метаболизма. mTOR также принимает участие в процессе активации макрофагов. Тема представленного обзора литературы: роль mTOR в репрограммировании макрофагов, в том числе опухоль-ассоциированных. Для поиска информации использовалась база данных PubMed.

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Макрофаги, опухоль, репрограммирование

Короткий адрес: https://sciup.org/149135498

IDR: 149135498

Список литературы Роль MTOR в репрограммировании опухоль-ассоциированных макрофагов и в канцерогенезе (обзор)

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