Role of neuregulins and hepatocyte growth factor in the development of castration-resistant prostate cancer

The development of castration-resistant prostate cancer is an important problem of modern oncology. The review is focused on the system of growth factors - neuregulins and hepatocyte growth factor (HGF), direct pathligands of ErbB tyrosine protein kinases and hepatocyte growth factor receptor, c-Met, the activation of which triggers a cascade of signaling pathways, ending by the stimulation of proliferation of cancer cells, their migration under conditions of the development of tolerance to the treatment of castration.