Роль нейрегулинов и фактора роста гепатоцитов в развитии кастрационно-рефрактерного рака предстательной железы

Роль нейрегулинов и фактора роста гепатоцитов в развитии кастрационно-рефрактерного рака предстательной железы

Автор: Спирина Людмила Викторовна, Усынин Евгений Анатольевич, Слонимская Елена Михайловна, Кондакова Ирина Викторовна, Горбунов А.К.

Журнал: Сибирский онкологический журнал @siboncoj

Рубрика: Обзоры

Статья в выпуске: 4 (70), 2015 года.

Бесплатный доступ

Развитие кастрационно-резистентного рака предстательной железы является важной проблемой современной онкологии, ухудшающей течение и качество жизни пациентов. Основное внимание в обзоре сосредоточено на системе ростовых факторов - нейрегулинов и факторе роста гепатоцитов (HGF) - непосредственных лигандов тирозиновых протеинкиназ ErbB и рецептора фактора роста гепатоцитов c-Met, активация которых запускает каскад сигнальных путей, завершающийся стимуляцией пролиферации раковых клеток, их миграцией в условиях развития нечувствительности к кастрационному лечению.

Рак предстательной железы, нейрегулины

Короткий адрес: https://sciup.org/14056566

IDR: 14056566

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