Роль отдельных субпопуляций CD4+ Т - лимфоцитов в патогенезе ВИЧ - инфекции

Автор: Сайдакова Е.В.

Журнал: Вестник Пермского университета. Серия: Биология @vestnik-psu-bio

Статья в выпуске: 3, 2020 года.

Бесплатный доступ

Пул CD4+ Т-лимфоцитов состоит из клеток различной степени зрелости. Наивные CD4+ Т-лимфоциты, стволовые CD4+ Т-клетки памяти, CD4+ Т-лимфоциты центральной и эффекторной памяти выполняют различные функции в поддержании гомеостаза иммунной системы. Несмотря на фенотипические различия, клетки каждой из этих субпопуляций могут быть инфицированы ВИЧ. При этом особенности CD4+ Т-лимфоцитов разной степени зрелости определяют роль этих клеток в патогенезе ВИЧ-инфекции. По изменению субпопуляционного состава периферических CD4+ Т-лимфоцитов ВИЧ-инфицированных больных можно судить о степени пораженности иммунной системы, а также делать прогнозы эффективности ее восстановления при назначении высокоактивной антиретровирусной терапии. В статье систематизированы основные события, происходящие с CD4+ Т-клетками различной степени зрелости в условиях неконтролируемого течения ВИЧ-инфекции и на фоне антиретровирусной терапии.

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Вич-инфекция, cd4+ т-клетки, наивные т-лимфоциты, т-клетки центральной памяти, т-клетки эффекторной памяти, стволовые т-клетки памяти, антиретровирусная терапия

Короткий адрес: https://sciup.org/147229658

IDR: 147229658 | DOI: 10.17072/1994-9952-2020-3-236-246

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