The role of protein kinase C, ERK-kinase, NO-synthase, and katp-channels in the mechanism of antiarrhythmic effect of the kappa opioid, U-50,488, during short\term myocardial ischemia and reperfusion in vivo
Автор: Maslov L.N., Lishmanov A.Yu., Tsibulnikov S.Yu.
Журнал: Сибирский журнал клинической и экспериментальной медицины @cardiotomsk
Рубрика: Лабораторные и экспериментальные исследования
Статья в выпуске: 1 т.28, 2013 года.
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The selective 1opioid receptor agonist, ()U50,488, increases cardiac tolerance to arrhythmogenic impact of short term ischemia and reperfusion via activation of NOsynthase, protein kinase C, and opening of KATPchannels. MEK1/2 and ERK1/2 kinases are not involved in the development of antiarrhythmic effect of ()U50,488.
Ischemia, reperfusion, heart, arrhythmias, opioid receptors, protein kinases
Короткий адрес: https://sciup.org/14919831
IDR: 14919831
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