The role of the effect of diabetic nephropathy on wound healing in patients with severe complications of diabetic foot syndrome

Background. The issues of pathogenesis, clinical picture, diagnosis and treatment of the associated course of chronic kidney disease (CKD) and diabetic foot syndrome are relevant and little studied. Methodology for revealing the research problem. 65 patients (prospectively) with type 2 diabetes and severe complications of diabetic foot were examined. Research methods included: general clinical, biochemical and instrumental studies, etc. Research results. Differences in peripheral arterial disease, severity of infection, and diabetic retinopathy were statistically significant between the two groups (p = 0.020, p = 0.020, and p = 0.001, respectively). There were no significant differences between groups in age, sex, duration and type of diabetes, smoking, alcoholism, hypertension, hypercholesterolemia, coronary artery disease, neuropathy, HbA1c, distal pulse, duration of wound infection, and severity of infection. The duration of ulcers in patients with CKD and patients without CKD was 15 (3.75; 26.50) and 8 (3; 24.25) weeks, respectively (p = 0.471). Recovery rates were 66.1% (n = 32) for patients with CKD and 81.3% (n = 33) for patients without CKD (p = 0.457).