Role of leptin in metabolic adaptation during cold acclimation

Role of leptin in metabolic adaptation during cold acclimation

Автор: Tang Gang-Bin, Tang Xiang-Fang, Li Kui, Wang De-Hua

Журнал: Журнал стресс-физиологии и биохимии @jspb

Статья в выпуске: 4 т.9, 2013 года.

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Chronic cold exposure stimulates thermogenesis in brown adipose tissue, resulting in fat mobilization and compensatory hyperphagia. Mostly, these physiological events are accompanied by a remarkable reduction in serum leptin levels. However, the physiological roles of hypoleptinemia in cold adaptation are still not fully clear. We hypothesized that leptin is the keystone of the regulatory systems linking energy balance to cold adaptation. Leptin treatment (5μg/day) decreased food intake, body weight, serum ghrelin levels and hypothalamic melanin-concentrating hormone (MCH) gene expression. Food restriction in the pair-fed group mimicked most of the effects induced by leptin treatment. Central coadministration of ghrelin (1.2 μg/day) partially reversed the effect of leptin on hypothalamic MCH mRNA, but it did not block the reducing effects of leptin on food intake, body weight and serum ghrelin levels. In addition, hypothalamic pro-opiomelanocortin gene expression increased significantly in response to the coadministration of leptin and ghrelin. Collectively, we conclude that the regulatory effects of leptin on energy balance in cold-acclimated rats are dependent on feeding, which may involve the reduction of hypothalamic MCH gene expression. We found no evidence for ghrelin involvement in the regulation of leptin on food intake and body weight during cold acclimation.

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Cold, leptin, mch, metabolism

Короткий адрес: https://sciup.org/14323792

IDR: 14323792

Список литературы Role of leptin in metabolic adaptation during cold acclimation

  • Abelenda, M., Ledesma, A., Rial, E., and Puerta, M. (2003). Leptin administration to cold-acclimated rats reduces both food intake and brown adipose tissue thermogenesis. Jour. Therm. Biol., 28, 525-530
  • Ahima, R.S., Prabakaran, D., Mantzoros, C., Qu, D.Q., Lowell, B., MaratosFlier, E., and Flier, J.S. (1996). Role of leptin in the neuroendocrine response to fasting. Nature, 382, 250-252
  • Bing, C., Frankish, H.M., Pickavance, L., Wang, Q., Hopkins, D.F., Stock, M.J., and Williams, G. (1998). Hyperphagia in cold-exposed rats is accompanied by decreased plasma leptin but unchanged hypothalamic NPY. Am. Jour. Physiol., 274, R62-68
  • Chi, Q.-S., and Wang, D.-H. (2011). Thermal physiology and energetics in male desert hamsters (Phodopus roborovskii) during cold acclimation. Jour. Comp. Physiol. B, 181, 91-103
  • Cowley, M.A., Smith, R.G., Diano, S., Tschop, M., Pronchuk, N., Grove, K.L., Strasburger, C.J., Bidlingmaier, M., Esterman, M., Heiman, M.L., et al. (2003). The distribution and mechanism of action of ghrelin in the CNS demonstrates a novel hypothalamic circuit regulating energy homeostasis. Neuron, 37, 649-661
  • De Jonghe, B.C., Hayes, M.R., Banno, R., Skibicka, K.P., Zimmer, D.J., Bowen, K.A., Leichner, T.M., Alhadeff, A.L., Kanoski, S.E., Cyr, N.E., et al. (2011). Deficiency of PTP1B in POMC neurons leads to alterations in energy balance and homeostatic response to cold exposure. Am. Jour. Physiol. Endocrinol. Metab., 300, E1002-1011
  • Friedman, J.M., and Halaas, J.L. (1998). Leptin and the regulation of body weight in mammals. Nature, 395, 763-770
  • Gualillo, O., Caminos, J.E., Nogueiras, R., Seoane, L.M., Arvat, E., Ghigo, E., Casanueva, F.F., and Dieguez, C. (2002). Effect of food restriction on ghrelin in normal-cycling female rats and in pregnancy. Obes. Res., 10, 682-687
  • Hakansson, M.L., Brown, H., Ghilardi, N., Skoda, R.C., and Meister, B. (1998). Leptin receptor immunoreactivity in chemically defined target neurons of the hypothalamus. Jour. Neurosci, 18, 559-572
  • Halaas, J.L., Gajiwala, K.S., Maffei, M., Cohen, S.L., Chait, B.T., Rabinowitz, D., Lallone, R.L., Burley, S.K., and Friedman, J.M. (1995). Weight-reducing effects of the plasma protein encoded by the obese gene. Science, 269, 543-546
  • Heiman, M.L., Sloop, K.W., Chen, Y., and Caro, J.F. (1999). Extension of neuroendocrine axes to include leptin. Jour. Anim. Sci., 77, 33-42
  • Kim, M.S., Namkoong, C., Kim, H.S., Jang, P.G., Kim Pak, Y.M., Katakami, H., Park, J.Y., and Lee, K.U. (2004). Chronic central administration of ghrelin reverses the effects of leptin. Int. Jour. Obes. Relat. Metab. Disord., 28, 1264-1271
  • Kojima, M., Hosoda, H., Date, Y., Nakazato, M., Matsuo, H., and Kangawa, K. (1999). Ghrelin is a growth-hormone-releasing acylated peptide from stomach. Nature, 402, 656-660
  • Lowry, O.H., Rosebrough, N.J., Farr, A.L., and Randall, R.J. (1951). Protein measurement with the Folin phenol reagent. Jour. Biol. Chem., 193, 265-275
  • Macdonald, I., and Siyamak, A. (1990). Plasma noradrenaline levels and thermogenic responses to injected noradrenaline in the conscious rat. Exp. Physiol., 75, 639-648
  • Masuzaki, H., Ogawa, Y., Isse, N., Satoh, N., Okazaki, T., Shigemoto, M., Mori, K., Tamura, N., Hosoda, K., Yoshimasa, Y., et al. (1995). Adipocyte-specific expression and regional differences in the adipose tissue. Diabetes, 44, 855-858
  • Nakazato, M., Murakami, N., Date, Y., Kojima, M., Matsuo, H., Kangawa, K., and Matsukura, S. (2001). A role for ghrelin in the central regulation of feeding. Nature, 409, 194-198
  • Pelleymounter, M.A., Cullen, M.J., Baker, M.B., Hecht, R., Winters, D., Boone, T., and Collins, F. (1995). Effects of the obese gene product on body weight regulation in ob/ob mice. Science, 269, 540-543
  • Pereira-da-Silva, M., Torsoni, M.A., Nourani, H.V., Augusto, V.D., Souza, C.T., Gasparetti, A.L., Carvalheira, J.B., Ventrucci, G., Marcondes, M.C., Cruz-Neto, A.P., et al. (2003). Hypothalamic melanin-concentrating hormone is induced by cold exposure and participates in the control of energy expenditure in rats. Endocrinology, 144, 4831-4840
  • Spiegelman, B.M., and Flier, J.S. (2001). Obesity and the regulation of energy balance. Cell, 104, 531-543
  • Sucajtys-Szulc, E., Turyn, J., Goyke, E., Korczynska, J., Stelmanska, E., Slominska, E., Smolenski, R.T., Rutkowski, B., and Swierczynski, J. (2010). Differential effect of prolonged food restriction and fasting on hypothalamic malonyl-CoA concentration and expression of orexigenic and anorexigenic neuropeptides genes in rats. Neuropeptides, 44, 17-23
  • Tang, G.B., Cui, J.G., and Wang, D.H. (2009). Role of hypoleptinemia during cold adaptation in Brandt's voles (Lasiopodomys brandtii). Am. J. Physiol. Regul. Integr. Comp. Physiol., 297, R1293-1301
  • Torsoni, M.A., Carvalheira, J.B., Pereira-Da-Silva, M., de Carvalho-Filho, M.A., Saad, M.J., and Velloso, L.A. (2003). Molecular and functional resistance to insulin in hypothalamus of rats exposed to cold. Am. Jour. Physiol. Endocrinol. Metab., 285, E216-223
  • Webber, J., and Macdonald, I.A. (2000). Signalling in body-weight homeostasis: neuroendocrine efferent signals. Proc. Nutr. Soc., 59, 397-404
  • Yang, J., Bromage, T.G., Zhao, Q., Xu, B.H., Gao, W.L., Tian, H.F., Tang, H.J., Liu, D.W., and Zhao, X.Q. (2011). Functional evolution of leptin of Ochotona curzoniae in adaptive thermogenesis driven by cold environmental stress. PLoS. One., 6, e19833
  • Zhang, Y., Proenca, R., Maffei, M., Barone, M., Leopold, L., and Friedman, J.M. (1994). Positional cloning of the mouse obese gene and its human homologue. Nature, 372, 425-432
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