Семафорин SEMA4D в иммунной системе
Автор: Куклина Е.М., Валиева Ю.В.
Журнал: Вестник Пермского университета. Серия: Биология @vestnik-psu-bio
Рубрика: Медико-биологические науки
Статья в выпуске: 3, 2018 года.
Бесплатный доступ
Семафорин IV класса Sema4D, подобно другим членам семейства семафоринов, играет ключевую роль в процессах аксонального наведения в ходе роста нейронов. Однако его эффекты в организме не ограничиваются регуляцией нейрогенеза - Sema4D широко представлен также в иммунной системе и контролирует различные формы иммунного ответа. В настоящей работе представлен детальный анализ иммунорегуляторных эффектов Sema4D in vitro и in vivo, с особым акцентом на рецепторах для семафорина в иммунной системе и механизмах реализации Sema4D-зависимых эффектов в иммунных клетках. Актуальность работы диктуется тем, что данный семафорин рассматривается в настоящее время как перспективная терапевтическая мишень в лечении целого ряда заболеваний, и применение такой терапии требует четкого понимания роли Sema4D в контроле иммунитета.
Лимфоциты, моноциты, дендритные клетки, иммунный ответ
Короткий адрес: https://sciup.org/147227037
IDR: 147227037
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