Семафорин SEMA4D в иммунной системе

Автор: Куклина Е.М., Валиева Ю.В.

Журнал: Вестник Пермского университета. Серия: Биология @vestnik-psu-bio

Статья в выпуске: 3, 2018 года.

Бесплатный доступ

Семафорин IV класса Sema4D, подобно другим членам семейства семафоринов, играет ключевую роль в процессах аксонального наведения в ходе роста нейронов. Однако его эффекты в организме не ограничиваются регуляцией нейрогенеза - Sema4D широко представлен также в иммунной системе и контролирует различные формы иммунного ответа. В настоящей работе представлен детальный анализ иммунорегуляторных эффектов Sema4D in vitro и in vivo, с особым акцентом на рецепторах для семафорина в иммунной системе и механизмах реализации Sema4D-зависимых эффектов в иммунных клетках. Актуальность работы диктуется тем, что данный семафорин рассматривается в настоящее время как перспективная терапевтическая мишень в лечении целого ряда заболеваний, и применение такой терапии требует четкого понимания роли Sema4D в контроле иммунитета.

Еще

Лимфоциты, моноциты, дендритные клетки, иммунный ответ

Короткий адрес: https://sciup.org/147227037

IDR: 147227037

Список литературы Семафорин SEMA4D в иммунной системе

Adachi T. et al. The B cell surface protein CD72 recruits the tyrosine phosphatase SHP-1 upon tyro-sine phosphorylation // Journal of Immunology. 1998. Vol. 160. P. 4662-4665.
Bougeret C. et al. Increased surface expression of a newly identified 150-kDa dimer early after human T lymphocyte activation // Journal of Immunology. 1992. Vol. 148. P. 318-323.
Chabbert-de Ponnat I. et al. Soluble CD100 functions on human monocytes and immature dendritic cells require plexin C1 and plexin B1, respectively // International Immunology. 2005. Vol. 17. P. 439-447.
Elhabazi A. et al. The human semaphorin-like leukocyte cell surface molecule CD100 associates with a serine kinase activity // Journal of Biological Chemistry. 1997. Vol. 272. P. 23515-23520.
Elhabazi A. et al. Biological activity of soluble CD100. I. The extracellular region of CD100 is released from the surface of T lymphocytes by regulated proteolysis // Journal of Immunology. 2001. Vol. 16. P. 4341-4347.
Evans E. et al. Antibody Blockade of Semaphorin 4D Promotes Immune Infiltration into Tumor and Enhances Response to Other Immunomodulatory Therapies // Cancer Immunology. 2015. Vol. 3. P. 689-701.
Granziero L. et al. CD100/Plexin-B1 interactions sustain proliferation and survival of normal and leu-kemic CD5 B lymphocytes // Blood. 2003. Vol. 101 (5). P. 1962-1969.
Hall K.T. et al. Human CD100, a novel leukocyte semaphorin that promotes B-cell aggregation and differentiation // Proceedings of the National Academy of Sciences. 1996. Vol. 93 (21). P. 11780-11785.
He Y. et al. CD100 up-regulation induced by inter-feron-a on B cells is related to hepatitis C virus infection // PLoS One. 2014. Vol. 9. P. 1-15.
Herold C. et al. CD100 is associated with CD45 at the surface of human T lymphocytes. Role in T cell homotypic adhesion // Journal of Immunology. 1996. Vol. 157. P. 5262-5268.
Hiraguchi Y. et al. Semaphorin 4D is expressed con-stitutively by human eosinophils // Allergology International. 2015. Vol. 64. P. S77eS79.
Janssen B.J. et al. Structural basis of semaphorin-plexin signaling // Nature. 2010. Vol. 467. P. 1118-1122.
Ishida I. et al. Involvement of CD100, a lymphocyte semaphorin, in the activation of the human immune system via CD72: implications for the regulation of immune and inflammatory responses // International Immunology. 2003. Vol. 15. P. 1027-1034.
Kolodkin A.L., Matthes D.J., Goodman C.S. The semaphorin genes encode a family of transmem-brane and secreted growth cone guidance molecules // Cell. 1993. Vol. 75. P. 1389-1399.
Kumanogoh A. et al. Identification of CD72 as a lymphocyte receptor for the class IV semaphorin CD100: a novel mechanism for regulating B cell signaling // Immunity. 2000. Vol. 13. P. 621-631.
Kumanogoh A., Kikutani H. The CD100-CD72 interaction: a novel mechanism of immune regulation // Trends in Immunology. 2001. Vol. 22 (12). P. 670-676.
Kumanogoh A. et al. Requirement for the lymphocyte semaphorin, CD100, in the induction of antigen-specific T cells and the maturation of dendritic cells // Journal of Immunology. 2002. Vol. 169. P. 1175-1181.
Kumanogoh A. et al. Requirement for CD100-CD72 interactions in fine-tuning of B-cell antigen receptor signaling and homeostatic maintenance of the B-cell compartment // International Immunology. 2005. Vol. 17. P. 1277-1282.
Love C.A. et al. The ligand-binding face of the sema-phorins revealed by the high-resolution crystal structure of SEMA4D // Nature Structural Biology. 2003. Vol. 10. P. 843-848.
Masuda K. et al. Sema4D stimulates axonal outgrowth of embryonic DRG sensory neurons // Cenes to Cells. 2004. Vol. 9. P. 321-829.
Mizrahi S. et al. CD100 on NK cells enhance IFNgamma secretion and killing of target cells expressing CD72 //PLoS One. 2007. Vol. 2 (9). P. e818.
Pan C., Baumgarth N., Parnes J. R. CD72-deficient mice reveal nonredundant roles of CD72 in B cell development and activation // Immunity. 1999. Vol. 11. P. 495-506.
Semaphorin Nomenclature Committee. Unified nomenclature for the semaphorins/collapsins // Cell. 1999. Vol. 97. P. 551-552.
Roney K.E. et al. Plexin-B2 negatively regulates macrophage motility, Rac, and Cdc42 activation // PLoS One. 2011. Vol. 6 (9). P. e24795.
Shi W. et al. The class IV semaphorin CD100 plays nonredundant roles in the immune system: defective B and T cell activation in CD100-deficient mice // Immunity. 2000. Vol. 13. P. 633-642.
Tamagnone L. et al. Plexins are a large family of receptors for transmembrane, secreted, and GPI-anchored semaphorins in vertebrates // Cell. 1999. Vol. 99. P. 71-80.
Tutt Landolfi M., Scollay R., Parnes R. Specific de-methylation of the CD4 gene during CD4 T lymphocyte differentiation // Molecular Immunology. 1997. Vol. 34. P. 53-61.
Wang X. et al. Functional soluble CD100/Sema4D released from activated lymphocytes: possible role in normal and pathologic immune responses // Blood. 2001. Vol. 97. P. 3498-3504.
Witherden A. et al. The CD100 receptor interacts with its plexin B2 ligand to regulate epidermal y5 T cell function // Immunity. 2012. Vol. 37 (2). P. 314-325.
Zhang Y. et al. Sema 4D/CD100-plexin B is a multifunctional counter-receptor // Cellular & Molecular Immunology. 2013. Vol. 10 (2). P. 97-98.

Еще

Статья научная