Synthesis of 1-[3- (phenoxy) benzyl]-5-(phenylamino) uracil deivatives as potential inhibitor of hepatitis C virus reproduction

Using condensation of 2,4-bis(trimethylsilyloxy)-5-(phenylamino)pyrimidines achieved by silylation from corresponding 5-(phenylamino)uracils, with 3-(phenoxy)benzyl bromide in 1,2-dichloroethane solution by boiling we prepared 1-[3-(phenoxy)benzyl]-5-(phenylamino)uracils containing substituents in the phenylamino fragment. The yield of target compounds was 61-82 %.