Part of parameters of immune and cytokine status at pregnant patients with purulent pyelonephritis

The purpose of the research was the study of cellular immune status and serum cytokines at pregnant patients with pyelonephritis. We have studied 106 pregnant with purulent pyelonephritis. 50 patients with serous pyelonephritis s and 30 healthy pregnant were the group of control. Clinical, microbiological and immunological methods of research have been used. Distinctions in parameters of cellular immune status and serum level of interleukin-1-betta, interleukin-8, interleukin-4, interleukin-10 and interferon-gamma at pregnant patients with serous and purulent pyelonephritis were determined. Deep depression of cellular immunity, the increase of serum concentration of interleukin-1b, interleukin-8, interleukin-4, interleukin-10 and lower contents of interferon-gamma were registered at pregnant patients with purulent pyelonephritis. Most radical immune changes at patients with apostems and renal abscess were registered. Criteria of early diagnostics of a bacterial shock by pyelonephritis in pregnancy are offered.