Systemic clinical manifestations of androgen deficiency in middle-aged men

Androgen deficiency presents with a wide range of systemic clinical manifestations affecting physical, psycho-emotional, and sexual health in middle-aged men. Common symptoms include chronic fatigue, decreased libido, depressive disorders, muscle weakness, and osteopenia. This article systematizes the main clinical manifestations of androgen deficiency and analyzes their pathogenetic mechanisms and diagnostic relevance.