Conjugacy between processes of systemic inflammation and systemic endotoxinemia in endogenous psychoses

Objective of the study: to analyze the conjugacy of processes of systemic inflammation and systemic endotoxinemia in relation to the clinical characteristics of patients with endogenous psychoses (EGP) before and after psychopharmacotherapy. Material and Methods: the study includes 25 patients with schizophrenia (F20.0 (0-1) according to ICD-10) and schizoaffective psychosis (F25.0), examined at admission to the hospital (in an acute psychotic state) and before discharge (after performed pharmacotherapy). The control group consists of 25 healthy persons. Markers of systemic inflammation (activity of leukocyte elastase (LE), functional activity of a1-proteinase inhibitor (a1-PI), level of antibodies (AB) to S100B and MBP), as well as parameters of systemic endotoxinemia (SET) (endotoxin concentration, level and the ratio of antiendotoxin antibodies) in blood are determined. Results: in an acute psychotic state (at baseline), an increase in the activity of LE and a1-PI is revealed in the group of patients in comparison with the control group (p