The condition of mitochondria and myocardial hypertrophy during the development of streptozotocin-induced diabetes associated with experimental myocardial infarction

The purpose of this study was to examine changes in morphometric parameters of rats with experimental myocardial infarction and diabetes mellitus at different stages of induced pathologies. It was shown that the combination of myocardial infarction and diabetes led to the decrease in the degree of cardiac hypertrophy (compared to myocardial infarction). Body weight decrease was less pronounced in all groups with a combination of pathologies (compared to animals with diabetes). At the cellular level, an increase in free mitochondrial respiration in hearts under all pathologies was shown. In the case of myocardial infarction+diabetes, uncoupling of oxidation and phosphorylation was less pronounced. Preservation of the parameters was not accompanied by preservation of the structure of cardiomyocytes.