Vascular-thrombocytic part of hemostasis in the long-term postoperative period in children underwent spleen surgeries

The aim of the study was to study the effect of the selected operation on spleen injury in children on changes in the indices of the vascular-platelet link of the hemostasis system in the long-term postoperative period. Materials and methods. A study was made of the aggregation activity of platelets and their carbohydrate composition in 56 children who underwent operations on the spleen in connection with its damage within a period of not less than 1 year. Aggregation of platelets was carried out using a laser analyzer aggregation "Biola 230". Inductors of aggregation of washed-out platelets were vegetable lectins: concanavalin A (CoA), wheat germ lectin (WGA) and phytohemagglutinin R-PHA-P. Results. It was found that splenectomy leads to an increase in aggregation properties of platelets in the long-term postoperative period due to glycoprotein receptors of b-D-galactose, N-acetyl-D-glucosamine and N-acetyl-neuraminic (sialic) acid. And a greater value is given to glycoprotein receptors containing b-D-galactose. The use of autolyentransplantation partially prevents changes in aggregation activity of platelets in the long-term postoperative period. After autolyentransplantation, the platelet aggregation activity is increased due to manoso-containing areas. Changes in aggregation activity of platelets after splenectomy lead to the development of complications in 42.8% of observations.