Improvement of therapy in children with comorbid course of glomerulonephritis with background pathology

In order to improve therapy in children with a comorbid course of glomerulonephritis with background pathology, 55 children aged 7 to 11 years old, suffering from nephrotic form of chronic glomerulonephritis (CGN) and lymphatic diathesis (LD), were examined. Of these: 35 - CGN against the background of LD-1 - group; 25- LD- 2-group. It was determined that in the comorbid course of the nephrotic form of chronic glomerulonephritis in children with lymphatic diathesis, the immune status is characterized by the development of multi-link immunological insufficiency (cellular, humoral, impaired production of IL-2, C3, C4 complement components), which persists during remission. The nephrotic form of chronic glomerulonephritis in children against the background of lymphatic diathesis is characterized by a violation of the alternative pathway of regulation with a low level of serum C3, C4 complement components. The high therapeutic efficiency of systemic enzyme therapy with wobenzym in the complex treatment of the nephrotic form of chronic glomerulonephritis against the background of lymphatic diathesis allows it to be recommended for use in the treatment of such patients.