Modern concepts on carcinogenesis: the value of insufficiency of malignant cell elimination mechanisms in the tumor progression in case of neoplasia at different localizations
Автор: Chesnokova N., Morrison V.V., Barsukov V.Yu., Ponukalina E.V., Agabekov A.I.
Журнал: Саратовский научно-медицинский журнал @ssmj
Рубрика: Физиология и патофизиология
Статья в выпуске: 1 т.12, 2016 года.
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The article presents the review of contemporary concepts of tumor induction mechanisms applicable for neoplastic transformation, promotion and proliferation. The paper also contains an in-depth analysis of results of authors'' own observations and study of immunological protection mechanisms of a significant number of patients diagnosed with oncopathologies of mammary and thyroid glands as well as adenocarcinoma of ascending colon. We have established common development patterns of T-cell and B-cell immunodeficiencies that are not influenced by location and proliferation of neoplastic tumors; the progress of such immunodeficincies, however, depends on regional metastasis development. Thus, we can conclude that insufficiency of immunological defense mechanisms leading to disruption of maligned cell elimination process is the primary pathogenic factor for metastatic tumor development.
Carcinogenesis, immunodeficiency, tumor progression
Короткий адрес: https://sciup.org/14918224
IDR: 14918224